Blockade of Kv1.5 by paroxetine, an antidepressant drug
نویسندگان
چکیده
منابع مشابه
Blockade of Kv1.5 by paroxetine, an antidepressant drug
Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been reported to have an effect on several ion channels including human ether-a-go-go-related gene in a SSRI-independent manner. These results suggest that paroxetine may cause side effects on cardiac system. In this study, we investigated the effect of paroxetine on Kv1.5, which is one of cardiac ion channels. The action of parox...
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The effects of paroxetine, a selective serotonin reuptake inhibitor, on human ether-a-go-go-related gene (HERG) channels were investigated using the whole-cell patch-clamp technique. The HERG channels were stably expressed in human embryonic kidney cells. Paroxetine inhibited the peak tail currents of the HERG channel in a concentration-dependent manner, with an IC50 value of 0.45 µM and a Hill...
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ژورنال
عنوان ژورنال: The Korean Journal of Physiology & Pharmacology
سال: 2016
ISSN: 1226-4512,2093-3827
DOI: 10.4196/kjpp.2016.20.1.75